# The apparent diffusion coefficient as a potential radiological biomarker of malignant transformation in retinoblastoma: a case report

## TL;DR

This case report shows that a drop in ADC values on MRI could signal cancer progression in retinocytoma, suggesting a new way to monitor patients.

## Contribution

This is the first report linking ADC changes to malignant transformation in retinocytoma.

## Key findings

- A distinct drop in ADC values correlated with clinical transformation to retinoblastoma.
- ADC changes may serve as a radiological biomarker for malignant conversion in retinocytoma.

## Abstract

We report a unique case of malignant transformation in a retinocytoma monitored using magnetic resonance imaging (MRI). This case is notable for a distinct drop in apparent diffusion coefficient (ADC) values that correlated with clinical transformation to retinoblastoma. This is the first report to highlight a change in ADC as a radiological marker of malignant conversion in retinocytoma. This finding suggests the potential role of ADC in prognostic assessment and risk stratification for patients with retinocytoma.