# Monte Carlo dosimetric characterization of the IRAsource high dose rate Iridium-192 brachytherapy source: Comparison with the mHDR-v2r model

**Authors:** Shuhei Tsuji, Christopher Njeh, Mohammadreza Hadizadeh, Mohammadreza Hadizadeh

PMC · DOI: 10.1371/journal.pone.0339841 · PLOS One · 2026-02-06

## TL;DR

This study compares the dosimetric properties of an IRAsource brachytherapy device with another model using detailed simulations.

## Contribution

The paper provides new Monte Carlo-based dosimetric data for the IRAsource and compares it with the mHDR-v2r model.

## Key findings

- The IRAsource dose rate constant was 1.1142±0.0030 cGyh−1U−1, consistent with prior data.
- The radial dose function of IRAsource matched mHDR-v2r at distances over 10 cm.
- The 2D anisotropy function showed up to 6% differences between IRAsource and mHDR-v2r at close distances.

## Abstract

The aim of this study was to evaluate the dosimetric characteristics of an IRAsource brachytherapy source using Monte Carlo simulations incorporating source electron effects. The dose rate constant, radial dose function, and two-dimensional (2D) anisotropy function were calculated and compared with those of published data and results of the mHDR-v2r source model. The dose rate constant obtained for the IRAsource was (1.1142±0.0030) cGyh−1U−1, which was consistent with previously reported values, within the range of experimental uncertainty. The radial dose function exhibited a pattern similar to that of the mHDR-v2r source, with dose distributions converging at distances of approximately 10 cm, where the effect of capsule thickness became negligible. The 2D anisotropy function did not fully align with other experimental datasets for the IRAsource. Even when comparing the IRAsource with mHDR-v2r sources, the 2D anithotropy function showed a difference of 3% to 6% around 0 degrees at distances of 0.25 cm to 5.0 cm from the source. The results reflected reasonable trends that were consistent with differences in source capsule geometry of the IRAsource and the mHDR-v2r. These findings show that the dosimetric data presented here is reliable. This study provides essential baseline data for accurate dose assessment of the IRAsource in brachytherapy and underscores the importance of further experimental validation to refine dose characterization.

## Full-text entities

- **Diseases:** cancer (MESH:D009369), CHARD (MESH:D062706)
- **Chemicals:** Mo (MESH:D008982), Ar (MESH:D001128), MCNP4C (-), Mn (MESH:D008345), Si (MESH:D012825), O (MESH:D010100), Cr (MESH:D002857), Fe (MESH:D007501), 192Ir (MESH:C000615087), N (MESH:D009584), stainless steel (MESH:D013193), water (MESH:D014867), Cu (MESH:D003300), Ni (MESH:D009532)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12880691/full.md

## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12880691/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12880691/full.md

---
Source: https://tomesphere.com/paper/PMC12880691