# Prognostic significance of CD44s expression in oral squamous cell carcinoma: An immuno-histo-chemical analysis

## TL;DR

This study shows that high CD44s expression in oral cancer is linked to worse outcomes and could help identify patients needing more aggressive treatment.

## Contribution

The study demonstrates CD44s as a potential prognostic biomarker for oral squamous cell carcinoma.

## Key findings

- High CD44s expression correlates with advanced cancer stage and lymph node metastasis.
- CD44s overexpression is associated with poor histological grade in oral cancer.
- CD44s may help identify high-risk oral cancer patients for targeted therapy.

## Abstract

Oral squamous cell carcinoma (OSCC) is a common malignancy with a poor prognosis, highlighting the need for reliable molecular
biomarkers. CD44s, a cell adhesion molecule, has been implicated in tumor progression, but its prognostic role in OSCC is unclear.
This retrospective study evaluated CD44s expression in 50 OSCC cases using immunohistochemistry and an immunoreactive scoring system.
High CD44s expression significantly correlated with advanced stage, lymph node metastasis and poor histological grade. CD44s overexpression
may serve as a prognostic biomarker to identify high-risk OSCC patients requiring aggressive therapy.