# Comparative analysis of general anaesthesia with and without dexmedetomidine in emergence agitation

**Authors:** Shalini Jain, Rasna K.P, Mohan Babu Nema, Manish Banjare

PMC · DOI: 10.6026/973206300214231 · Bioinformation · 2025-11-15

## TL;DR

This study compares general anesthesia with and without dexmedetomidine to see which is better at reducing emergence agitation after maxillofacial surgery.

## Contribution

The study demonstrates that dexmedetomidine effectively reduces emergence agitation and improves recovery quality in maxillofacial surgery patients.

## Key findings

- Dexmedetomidine significantly reduced the incidence and severity of emergence agitation.
- Dexmedetomidine improved sedation scores and hemodynamic stability without increasing pain or nausea.
- Bradycardia occurred more often with dexmedetomidine but was manageable.

## Abstract

Emergence agitation (EA) is a common concern in maxillofacial surgeries under general anaesthesia. Therefore, it is of interest to
evaluate the role of intraoperative dexmedetomidine infusion in its prevention. Ninety ASA I-II adult patients were randomized into two
groups general anaesthesia alone (Group A) and general anaesthesia with dexmedetomidine (Group B). Dexmedetomidine significantly reduced
the incidence and severity of EA (p <l0.001) improved sedation scores and provided better hemodynamic stability without increasing pain,
nausea or vomiting. Bradycardia was more frequent in the dexmedetomidine group but also manageable making it a safe and effective adjuvant
for enhancing recovery quality.

## Linked entities

- **Chemicals:** dexmedetomidine (PubChem CID 5311068)

## Full-text entities

- **Diseases:** EA (MESH:D000071257), Bradycardia (MESH:D001919), pain (MESH:D010146), nausea (MESH:D009325), vomiting (MESH:D014839)
- **Chemicals:** Dexmedetomidine (MESH:D020927)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12880155/full.md

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Source: https://tomesphere.com/paper/PMC12880155