# Salivary pH, uric acid and C - reactive protein in conventional versus chitosan-nanoparticle denture wearers

## TL;DR

This study shows that dentures with chitosan nanoparticles improve oral health by increasing saliva pH and uric acid while reducing inflammation.

## Contribution

The novel use of chitosan nanoparticles in dentures is shown to enhance oral health parameters in edentulous patients.

## Key findings

- CNP dentures significantly increased salivary pH and uric acid levels.
- CNP dentures showed a non-significant decrease in C-reactive protein (CRP).
- CNP incorporation improves oral health by modifying salivary parameters and reducing inflammation.

## Abstract

Edentulous patients wearing complete dentures often face poor denture hygiene and mucosal inflammation. Incorporating antimicrobial agents
such as chitosan nanoparticles (CNPs) into dentures may improve the oral environment. In this study, salivary pH, uric acid and C-reactive
protein (CRP) were compared between conventional dentures and CNP-incorporated dentures in edentulous patients. After one month of use, CNP\
dentures significantly increased salivary pH and uric acid while showing a non-significant decrease in CRP. Thus, we show that CNP
incorporation enhances oral health by improving salivary parameters and reducing inflammatory responses.