# Arsenicum iodatum and arseicum album induces apoptosis and autophagy in glioblastoma multiforme

## TL;DR

This study explores how two homeopathic remedies may help treat a deadly brain tumor by triggering cell death and autophagy.

## Contribution

The paper shows that Arsenicum iodatum and Arsenicum album induce apoptosis and autophagy in glioblastoma cells.

## Key findings

- Both Arsenicum iodatum and Arsenicum album induced apoptosis in U87 glioblastoma cells.
- Autophagy was triggered, as shown by reduced p62 levels.
- Inhibiting autophagy increased cell death, suggesting it protects GBM cells.

## Abstract

Glioblastoma multiforme (GBM) is a highly aggressive and treatment-resistant brain tumor, highlighting the need for novel therapeutic
strategies. Therefore, it is of interest to investigate the anti-cancer effects of Arsenicum iodatum and Arsenicum album in U87
glioblastoma cells at 6C, 12C and 30C potencies. Both preparations induced apoptosis, confirmed by TUNEL along with the caspase-3 assays
and triggered autophagy, evidenced by reduced p62 levels. Inhibition of autophagy enhanced cytotoxicity, indicating its protective role
in GBM cells. Thus, we show that Arsenicum iodatum and Arsenicum album may serve as complementary candidates for GBM therapy, warranting
further in vivo and mechanistic studies.