# Analytical study on metabolic syndrome and psoriasis severity: A cross sectional study

**Authors:** Amirtha Varshine Navaneeta Krishnan, Achal Ganiga Lingaraj, Amir Kammoun, Shravya Kanishka Mareboina, Sebah Elsa John, Joshua Chacko, Muhammed Nabeel Pullithodika

PMC · DOI: 10.6026/973206300214185 · Bioinformation · 2025-11-15

## TL;DR

This study finds a link between metabolic syndrome and more severe psoriasis, highlighting the need for metabolic screening in patients.

## Contribution

The study establishes a significant association between psoriasis severity and metabolic syndrome factors in a cross-sectional cohort.

## Key findings

- PASI scores were significantly higher in patients with metabolic syndrome.
- Central obesity and dyslipidemia were most strongly linked to elevated PASI scores.

## Abstract

Psoriasis is a chronic inflammatory skin disease increasingly linked to metabolic syndrome, yet the extent of this association remains
unclear. This cross-sectional study examined the relationship between psoriasis severity and metabolic syndrome among 122 adults with
chronic plaque psoriasis. Psoriasis Area and Severity Index (PASI) scores were significantly higher in patients with metabolic syndrome,
indicating greater disease severity. Central obesity and dyslipidemia were the most prevalent metabolic factors associated with elevated
PASI scores. Thus, we show the importance of routine metabolic screening in psoriasis patients to improve disease management and
outcomes.

## Linked entities

- **Diseases:** psoriasis (MONDO:0005083), metabolic syndrome (MONDO:0000816)

## Full-text entities

- **Diseases:** Psoriasis (MESH:D011565), metabolic syndrome (MESH:D024821), skin disease (MESH:D012871), inflammatory (MESH:D007249), dyslipidemia (MESH:D050171), obesity (MESH:D009765)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12880133/full.md

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Source: https://tomesphere.com/paper/PMC12880133