# Not just a goiter: Uncovering primary thyroid lymphoma

**Authors:** Venkata Kaumudi Ayaluri, Angel Jose, Harshitha Reddy, Arooba Khurram

PMC · DOI: 10.6026/973206300214039 · Bioinformation · 2025-11-15

## TL;DR

This paper presents a case of primary thyroid lymphoma in a 60-year-old woman, emphasizing the importance of early diagnosis and treatment.

## Contribution

The paper contributes a clinical case study highlighting the diagnostic challenges of primary thyroid lymphoma.

## Key findings

- A 60-year-old woman presented with a rapidly enlarging thyroid mass confirmed as non-Hodgkin lymphoma.
- Fine needle aspiration and biopsy were key in diagnosing the thyroid neoplasm as lymphoma.
- The case underscores the need for early diagnosis and tailored treatment for primary thyroid lymphoma.

## Abstract

Primary thyroid lymphoma (PTL) is a rare, aggressive neoplasm of the thyroid gland that occurs most frequently in older women. We
describe a 60-year-old woman who presented to our hospital with a primarily painless, progressively enlarging neck swelling over the
previous four months. Imaging showed an enlarged thyroid gland and mass effect in the surrounding neck soft tissue. Fine needle
aspiration revealed a predominance of lymphoid cells to suggest that this hypothesized mass was a thyroid neoplasm. Biopsy of the thyroid
gland confirmed non-Hodgkin lymphoma of the thyroid. She was treated with standard CHOP chemotherapy. This case highlights the conundrum
of PTL in a rapidly enlarging mass of the thyroid gland and the need to address this early with better diagnosis and therapeutic
plan.

## Linked entities

- **Diseases:** non-Hodgkin lymphoma (MONDO:0018908)

## Full-text entities

- **Diseases:** non-Hodgkin lymphoma of the thyroid (MESH:D008228), goiter (MESH:D006042), neoplasm of the thyroid gland (MESH:D013964), PTL (MESH:D008223), neck swelling (MESH:D006258)
- **Chemicals:** CHOP (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12880123/full.md

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Source: https://tomesphere.com/paper/PMC12880123