# MRI Features of Intravenous Leiomyomatosis

**Authors:** Beatriz Freixo, Delfim Doutel, Teresa Margarida Cunha

PMC · DOI: 10.5334/jbsr.4201 · Journal of the Belgian Society of Radiology · 2026-02-04

## TL;DR

This paper describes an MRI case study of a rare uterine tumor called intravenous leiomyomatosis in a 42-year-old woman.

## Contribution

The study highlights MRI features that can help identify intravenous leiomyomatosis, such as serpiginous intravascular extensions and absence of diffusion restriction.

## Key findings

- MRI showed a heterogeneous myometrial mass with serpiginous extensions along iliac veins.
- The lesion had high signal on high b-value diffusion-weighted images and high apparent diffusion coefficient values.
- Histopathology confirmed the diagnosis of intravenous leiomyomatosis after surgery.

## Abstract

Intravenous leiomyomatosis is a rare benign uterine smooth muscle tumor with intravascular growth through pelvic veins or lymphatics. A case is reported of a 42-year-old woman with intermittent spotting and progressive abdominal enlargement. Pelvic magnetic resonance imaging showed a heterogeneous myometrial mass with serpiginous extensions along iliac veins. The lesion had high signal on high b-value diffusion-weighted images and high apparent diffusion coefficient values, indicating the absence of diffusion restriction. After surgery, histopathology confirmed the diagnosis of intravenous leiomyomatosis.

Teaching point: Recognition of serpiginous intravascular extensions and the absence of diffusion restriction on magnetic resonance imaging should raise suspicion for intravenous leiomyomatosis.

## Linked entities

- **Diseases:** intravenous leiomyomatosis (MONDO:0003614)

## Full-text entities

- **Diseases:** smooth muscle tumor (MESH:D018235), Intravenous Leiomyomatosis (MESH:D018231)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

4 references — full list in the complete paper: https://tomesphere.com/paper/PMC12880008/full.md

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Source: https://tomesphere.com/paper/PMC12880008