# Animal models of antiphospholipid syndrome

## TL;DR

This paper reviews animal models used to study antiphospholipid syndrome, an autoimmune disorder linked to blood clots and pregnancy complications.

## Contribution

The paper systematically summarizes current paradigms in thrombotic and obstetric APS animal models.

## Key findings

- Animal models are essential for understanding APS mechanisms and developing therapies.
- Recent advances have improved the methodological and translational value of APS models.
- The review highlights advantages and limitations of different APS animal models.

## Abstract

Antiphospholipid syndrome (APS) is an autoimmune disorder defined by persistent antiphospholipid antibodies (aPL), thrombosis, and/or pathological pregnancy. Its phenotypic spectrum is heterogeneous and its pathogenesis remains incompletely understood. The incidence of APS increases year by year. Due to the constraints on human studies, animal models have become indispensable tools for dissecting the mechanisms of APS. The animal models accelerate the drug discovery and refine the therapeutic strategies in APS. Over the past decades, substantial methodological and translational advances have been achieved in APS animal models. In this review, we systematically summarize the current construction paradigms in thrombotic and obstetric APS animal models and highlight their respective advantages and limitations.