# 3D‐Printed Protein Models as an Educational Tool in Biochemistry Outreach

**Authors:** Oliver Osborne, Siobhan Clennell, Shaun K. Bremner‐Hart

PMC · DOI: 10.1002/bmb.70030 · Biochemistry and Molecular Biology Education · 2026-01-22

## TL;DR

3D-printed protein models helped students better understand protein structure and were found to be engaging and innovative in a classroom setting.

## Contribution

Introduces 3D-printed and virtual protein models as an effective educational tool for teaching protein structure in secondary schools.

## Key findings

- Students found the 3D-printed models enhanced their understanding of protein structure.
- Feedback showed the workshop was innovative and engaging for participants.
- Students expressed interest in future hands-on workshops using similar models.

## Abstract

The abstract and complex nature of molecular biology often presents significant challenges for students at all levels of study. Traditional teaching methods, such as the use of 2D diagrams, may not fully convey the intricacies of these topics, leading to difficulties in comprehension and engagement. This study aimed to introduce 3D‐printed and virtual protein models into a secondary school classroom to enhance students' understanding of protein structure. 3D models were designed using ChimeraX and were either 3D printed or hosted online as interactive virtual models. A PowerPoint presentation was used to introduce the concept of protein structure in a didactic manner. Next, students answered questions on worksheets using the protein models. These worksheets promoted inquiry‐based and self‐directed learning through research‐guided questions and challenges. Feedback revealed that students found the workshop innovative and engaging. All participants indicated that the 3D‐printed models enhanced their understanding of protein structure and expressed interest in future hands‐on workshops. These findings highlight the potential of modern, model‐based teaching approaches to improve comprehension of protein folding and structure.

## Full-text entities

- **Genes:** TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, CYGB (cytoglobin) [NCBI Gene 114757] {aka HGB, NOD, STAP}, POLB (DNA polymerase beta) [NCBI Gene 5423], TTN (titin) [NCBI Gene 7273] {aka CMD1G, CMH9, CMPD4, CMYO5, CMYP5, EOMFC}, MB (myoglobin) [NCBI Gene 4151] {aka MYOSB, PVALB}
- **Chemicals:** haem (MESH:D006418), hydrogen (MESH:D006859), carbohydrate (MESH:D002241), PLA (MESH:C033616), TPU (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12877977/full.md

## References

41 references — full list in the complete paper: https://tomesphere.com/paper/PMC12877977/full.md

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Source: https://tomesphere.com/paper/PMC12877977