# Resilience in motion: emerging perspectives on stress, substance use and youth

**Authors:** P. Sampedro-Piquero

PMC · DOI: 10.1016/j.ynstr.2026.100783 · Neurobiology of Stress · 2026-01-27

## TL;DR

This paper explores how exercise can help reduce stress and alcohol cravings in young people, potentially improving their emotional and cognitive health.

## Contribution

The study highlights the potential of tailored exercise interventions to enhance resilience in youth with risky alcohol use.

## Key findings

- Exercise reduced anxiety, craving, and enhanced memory in youths with RAU.
- Aerobic exercise and stretching promoted executive and emotional benefits.

## Abstract

Adolescence and young adulthood are developmental stages characterized by heightened stress sensitivity and limited cognitive control. The identification of the risk factors of alcohol consumption in these stages is crucial for early interventions focused on reducing harmful alcohol use. This review examines how exercise can modulate stress responses, reduce cravings, and preserve cognitive and emotional functioning. In animal models, it has been well described that exercise is able to reduce craving and protect cognitive and affective domains. Translational studies in young people with risky alcohol use (RAU) revealed comparable benefits. Acute aerobic exercise improved executive functions, such as verbal fluency, whereas stretching induced distinct neural oscillatory changes related to emotion regulation. These findings underscore the heterogeneous yet complementary effects of different exercise modalities, suggesting that tailored interventions may optimize outcomes. Future work will incorporate interoceptive measures to clarify the mechanisms linking stress dysregulation and RAU vulnerability, with particular attention to gender-related differences. Collectively, the evidence suggests that aerobic exercise may constitute a promising, feasible, and transdiagnostic intervention that strengthens stress-response systems, reduces craving, and fosters resilience in young people at risk of alcohol misuse, with women showing interoceptive deficits emerging as a particularly vulnerable subgroup.

•Exercise reduced anxiety, craving, and enhanced memory in youths with RAU.•Virtual reality enabled controlled assessment of stress and craving responses.•Aerobic exercise and stretching promoted executive and emotional benefits.•Interoceptive function in women with SUD could be improved by exercise.

Exercise reduced anxiety, craving, and enhanced memory in youths with RAU.

Virtual reality enabled controlled assessment of stress and craving responses.

Aerobic exercise and stretching promoted executive and emotional benefits.

Interoceptive function in women with SUD could be improved by exercise.

## Full-text entities

- **Diseases:** craving (MESH:C564883), alcohol misuse (MESH:D000437)
- **Chemicals:** alcohol (MESH:D000438)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12877815/full.md

## References

60 references — full list in the complete paper: https://tomesphere.com/paper/PMC12877815/full.md

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Source: https://tomesphere.com/paper/PMC12877815