# The Role of the Delta Neutrophil Index, Pan‐Immune Inflammation Value and Other Hematologic Inflammatory Parameters in the Preliminary Diagnosis of Tubal Ectopic Pregnancy

## TL;DR

This study explores whether blood markers like the delta neutrophil index and others can help diagnose ectopic pregnancy early on.

## Contribution

The study is the first to investigate the relationship between the delta neutrophil index, pan-immune inflammation value, and ectopic pregnancy.

## Key findings

- White blood cell count, platelet, lymphocyte, and other inflammatory markers were higher in ectopic pregnancy cases.
- Hemoglobin levels were lower in women with ectopic pregnancy compared to healthy intrauterine pregnancies.
- The delta neutrophil index did not show a significant difference between the two groups.

## Abstract

Differentiating between healthy intrauterine pregnancy (HP) and ectopic pregnancy (EP) in early gestation is clinically challenging.

This study aimed to evaluate the role of the delta neutrophil index (DNI), pan‐immun inflammation value (PIV) and other hematologic inflammatory markers in the preliminary diagnosis of tubal EP. To the best of our knowledge, there are no studies in the literature examining the relationship between DNI, PIV and EP.

This retrospective study included 120 women diagnosed with tubal EP and 102 women with HP who presented to a tertiary hospital in Turkey between 2019 and 2023. Inclusion criteria were women with confirmed tubal EP or HP who had complete clinical and hematologic data and no chronic diseases, infections, or body mass index (BMI) > 30 kg/m2. The primary outcome was to assess whether DNI, PIV and other complete blood count (CBC) parameters could differentiate EP from HP. Statistical analysis included t‐tests, Welch's t‐test, χ
2 tests, and ROC analysis; p < 0.05 was considered statistically significant.

No significant difference was found in DNI value (p = 0.256). However, white blood cell count (WBC) (p = 0.007), platelet (PLT) (p = 0.001), lymphocyte (p < 0.001), PIV (p = 0.023), systemic immune‐inflammation index (SII) (p = 0.016) and basophil (p = 0.005) levels were higher in the EP group, while hemoglobin (HB) levels were lower (p < 0.001).

While DNI was not a significant marker, other hematologic parameters may support early identification of EP, suggesting an underlying inflammatory process.