# Aromaticity-driven laser photo-responses and binding efficiency in IAF-conjugated natural products for neurodegenerative disease targets

**Authors:** Nik Humaidi Nik Zulkarnine, Vahid Faramarzi, Michael Taeyoung Hwang

PMC · DOI: 10.1038/s41392-025-02560-w · Signal Transduction and Targeted Therapy · 2026-02-06

## Full-text entities

- **Genes:** ADAM10 (ADAM metallopeptidase domain 10) [NCBI Gene 102] {aka AD10, AD18, CD156c, CDw156, HsT18717, MADM}, BACE1 (beta-secretase 1) [NCBI Gene 23621] {aka ASP2, BACE, HSPC104}, APP (amyloid beta precursor protein) [NCBI Gene 351] {aka AAA, ABETA, ABPP, AD1, APPI, CTFgamma}, MME (membrane metalloendopeptidase) [NCBI Gene 4311] {aka CALLA, CD10, CMT2T, NEP, SCA43, SFE}
- **Diseases:** AD (MESH:D000544), neurodegenerative disease (MESH:D019636)
- **Chemicals:** hydrogen (MESH:D006859), IAF (-), Oridonin (MESH:C011959), Ammosamide B (MESH:C534623), diterpenoid (MESH:D004224)

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Source: https://tomesphere.com/paper/PMC12876877