# Onion (Allium cepa L.) Organosulfur Compounds: From Traditional Use to Modern Pharmacological Insights

## TL;DR

Onions contain organosulfur compounds with potential health benefits, including lipid regulation, antibacterial, antitumor, and diabetes-fighting properties.

## Contribution

This review systematically analyzes the chemical diversity, extraction methods, and pharmacological mechanisms of onion organosulfur compounds.

## Key findings

- Onion OSCs regulate lipid metabolism and show antibacterial and antitumor effects.
- Extraction methods like supercritical CO2 offer advantages over traditional techniques.
- OSCs have hypoglycemic and anti-asthmatic potential, with future therapeutic applications.

## Abstract

Onion (
Allium cepa L.), as one of the earliest vegetables cultivated by humans, has a medicinal value that can be traced back to The times of ancient Egypt, Greece, and Rome. In recent years, with the development of analytical techniques and molecular biology, the unique organic sulfides (organosulfur compounds, OSCs) in onions have attracted extensive attention from the scientific community. This article conducts a detailed analysis of the chemical structural characteristics of the main organic sulfides in onions, compares the advantages and disadvantages of extraction techniques such as steam distillation, organic solvent extraction, and supercritical CO2 extraction, and elaborates on their mechanisms of action in regulating lipid metabolism, exerting antibacterial and antitumor effects, alleviating diabetes, and mitigating asthma. The article finally discusses the application prospects of onion organic sulfides in the treatment of diseases, as well as the current technical challenges, providing a reference for the determination of future research directions.

This review systematically examines the chemical diversity, extraction methods, and pharmacological activities of organosulfur compounds (OSCs) in onions. Key mechanisms include lipid metabolism regulation, anti‐bacterial and anti‐tumor effects, hypoglycemic activity, and anti‐asthmatic potential. The article highlights future directions for OSC‐based therapeutics amid current technical and clinical challenges.