# A case report on the diagnosis and treatment of a glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features

## TL;DR

This case report describes a rare brain tumor in a woman, diagnosed 22 years after her initial treatment, and treated with radiotherapy and chemotherapy.

## Contribution

The report provides insights into the diagnosis and treatment of a rare glioneuronal tumor subtype with ATRX alteration and kinase fusion.

## Key findings

- The patient was diagnosed with a rare GTAKA tumor 22 years after initial treatment for a grade 2 astrocytoma.
- Adjuvant radiotherapy and temozolomide chemotherapy were used as treatment for the new tumor.
- The case contributes to understanding the immunohistochemical and molecular features of GTAKA.

## Abstract

Glioneuronal tumor with ATRX alteration, kinase fusion, and anaplastic features (GTAKA) is a rare pathological subtype of the central nervous system, with currently limited research available. This case report details a 37-year-old woman who developed a new intracranial tumor 22 years after initial treatment (surgical resection and adjuvant radiotherapy) for a WHO grade 2 astrocytoma. The new lesion was histopathologically diagnosed as GTAKA, a distinct glioneuronal tumor entity, following which the patient received adjuvant radiotherapy with concomitant temozolomide chemotherapy. Although this pathological type is rare, the immunohistochemical and molecular findings, combined with the therapeutic approach in this case, contribute to a deeper understanding of the disease.