# High-resolution 3T-MRI with microcoil enhancement for preoperative evaluation of cutaneous squamous cell carcinoma: a case report and literature review

**Authors:** Shun Cao, Shaowei Zhan, Mengxiao Tang, Qiuyu Yu, Hongjie Hu

PMC · DOI: 10.3389/fmed.2026.1686516 · Frontiers in Medicine · 2026-01-23

## TL;DR

High-resolution MRI helps doctors better assess skin cancer before surgery, improving treatment planning and outcomes.

## Contribution

This case report demonstrates the effectiveness of high-resolution MRI in evaluating cutaneous squamous cell carcinoma preoperatively.

## Key findings

- HR-MRI provided clear visualization of tumor morphology and infiltration depth.
- It improved accuracy in delineating tumor boundaries compared to conventional MRI.
- The imaging helped confirm the tumor's relationship with surrounding structures without deeper tissue involvement.

## Abstract

Cutaneous squamous cell carcinoma (cSCC) is a common non-melanoma skin cancer with potential for local invasion and metastasis. Accurate preoperative assessment is essential for optimal treatment planning.

We report a case of an 83-year-old female patient who presented with a progressively enlarging scalp mass over 3 months. HR-MRI revealed a mixed-signal lesion (22 × 15 × 26 mm) in the right scalp. On T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI), the lesion exhibited heterogeneous signals with an irregular, crater-like surface. Post-contrast imaging demonstrated significant heterogeneous enhancement. The tumor was located within the epidermis, dermis, and subcutaneous fat, closely adhering to the galea aponeurotica with well-defined margins. Surgical resection and histopathological examination confirmed a (exophytic type) moderately to well-differentiated cSCC (2.8 × 2.3 × 2.0 cm) infiltrating the subcutaneous tissue but without perineural invasion or deeper tissue involvement.

HR-MRI provided clear visualization of tumor morphology, infiltration depth, and relationship with surrounding structures. Compared to conventional MRI, HR-MRI improved the accuracy of tumor boundary delineation, offering valuable information for preoperative planning.

HR-MRI plays a significant role in the evaluation of cSCC, particularly in assessing tumor infiltration depth and differentiating it from other cutaneous malignancies. Its high-resolution imaging facilitates early detection, precise surgical planning, and improved patient outcomes.

## Linked entities

- **Diseases:** cutaneous squamous cell carcinoma (MONDO:0002529), skin cancer (MONDO:0002898)

## Full-text entities

- **Diseases:** metastasis (MESH:D009362), Cutaneous squamous cell carcinoma (MESH:D002294), non-melanoma skin cancer (MESH:D012878), cutaneous malignancies (MESH:C562393), tumor (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12875906/full.md

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Source: https://tomesphere.com/paper/PMC12875906