# Investigation of a Family Cluster of Human Infections With Highly Pathogenic Avian Influenza A(H5N1) Virus, Clade 2.3.2.1e, in Cambodia, February 2023

## TL;DR

A family in Cambodia was infected with a deadly bird flu virus, likely from handling sick poultry, highlighting ongoing public health risks.

## Contribution

The study documents a family cluster of H5N1 infections in Cambodia and identifies poultry exposure as a likely source.

## Key findings

- An 11-year-old girl and her father were infected with H5N1 avian influenza in Cambodia.
- Exposure to sick and dead poultry is suspected as the source of infection.
- Control measures included culling poultry and community health education.

## Abstract

In February 2023, an 11‐year‐old girl in Cambodia developed severe respiratory symptoms and died of pneumonia and respiratory failure after testing positive for influenza A(H5). Contract tracing and testing identified her father as positive for influenza A(H5). Investigations revealed both were likely exposed to the same sick and dead poultry. Control measures included culling sick poultry and providing health education in the community on handling infected birds. Highly pathogenic avian influenza A(H5N1) viruses continue to pose public health risks in Cambodia.