# Spatiotemporal aggregation and population distribution characteristics of HIV/AIDS in Nanchang city: A monitoring analysis from 2012–2021

**Authors:** Li Wang, Liang Lu, Zhibin Tu, Liping Qiu, Xiaoqin Tong, Jinyi Sun, Rui Liu

PMC · DOI: 10.1371/journal.pone.0342375 · PLOS One · 2026-02-05

## TL;DR

This study analyzes how HIV/AIDS spread in Nanchang from 2012 to 2021, showing where and among whom infections are most common.

## Contribution

The study introduces a novel spatiotemporal analysis framework combining Joinpoint regression and geographic information technology.

## Key findings

- New HIV/AIDS cases grew at 5.4% annually, faster than population growth.
- Men and the elderly (≥65) are at higher risk of infection.
- Infections cluster in the city center and spread outward with population density.

## Abstract

AIDS is a major public health issue. As a transportation and economic hub in central China, Nanchang has frequent population mobility and unbalanced regional development, making it urgent to explore the prevalence characteristics of HIV/AIDS. Based on HIV/AIDS surveillance data in Nanchang from 2012 to 2021, this study innovatively integrates the Joinpoint regression model with spatiotemporal geographic information technology to construct an epidemiological analysis framework of “time-space-population”. The results show that a total of 3,789 HIV/AIDS infection cases were reported in the decade, with the growth rate of new cases (5.4%) significantly higher than the population growth rate (2.1%). There is a negative correlation between incidence and mortality, and men and the elderly (≥65 years old) are at prominent infection risk. Spatially, cases show significant heterogeneity, with “high-high” clustering areas concentrated in the city center and gradually expanding to surrounding areas, which is related to factors such as population density. The study provides a scientific basis for targeted interventions for men and the elderly, optimization of prevention and control strategies, and regional collaboration.

## Linked entities

- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** immunodeficiency disease (MESH:D007153), COVID-19 (MESH:D000086382), AIDS (MESH:D000163), death (MESH:D003643), infectious death (MESH:D003141), HIV infections (MESH:D015658), infected (MESH:D007239), SMSC (MESH:D015875)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Full text

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## Figures

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## References

35 references — full list in the complete paper: https://tomesphere.com/paper/PMC12875437/full.md

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Source: https://tomesphere.com/paper/PMC12875437