# Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies

## TL;DR

This review explores how glutamine metabolism interacts with tumor stromal components and discusses potential therapies targeting this process.

## Contribution

The paper provides a comprehensive overview of glutamine metabolism's role in tumor stromal interactions and highlights therapeutic strategies.

## Key findings

- Glutamine metabolism interacts with various stromal components like macrophages and fibroblasts in the tumor microenvironment.
- Current anti-tumor therapies targeting glutamine metabolism are summarized, highlighting their potential for clinical application.
- The study identifies gaps in understanding metabolic complexity and proposes future research directions.

## Abstract

As a critical metabolite in the tumor microenvironment, glutamine plays a crucial role in tumor progression, and its dual effects on promoting and inhibiting tumors have garnered increasing attention in recent years. Glutamine metabolism in tumor cells has been extensively studied; however, there is currently a lack of a comprehensive description of how it interacts with tumor stromal components in the tumor microenvironment. This review focuses on the interaction of glutamine metabolism and a range of tumor stromal components, such as macrophages, dendritic cells, T cells, fibroblasts, collagen, and blood vessels in the tumor microenvironment, as well as a summary of current prospective anti-tumor therapeutics targeting glutamine metabolism. Furthermore, this study discusses the shortcomings of mechanism research, metabolic complexity, and metabolic therapy for glutamine metabolism and proposes future research directions that are expected to provide a theoretical foundation for clinical cancer treatment strategies.

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