Berberine Alleviates Lipopolysaccharide‐Induced Impairments in Neuroplasticity and Spatial Memory by Modulating Microglial Polarization via MAPK Signaling Inhibition
Lirong Jiang, Ruiyi Liao, Jiaxin Wang, Yuan Yang, Jiaojiao Sun, Li Liu, Yiwei Wang, Wei Dong, Yang Yu
TL;DR
Berberine helps protect memory and brain plasticity by reducing harmful inflammation in the brain, potentially offering a treatment for cognitive impairments.
Contribution
This study demonstrates that berberine mitigates cognitive deficits by modulating microglial polarization via MAPK signaling inhibition.
Findings
BBR pretreatment improved cognitive performance and reduced hippocampal neuronal damage in a mouse model.
BBR suppressed microglial activation and increased functional dendritic spine density.
BBR inhibited phosphorylation of key proteins in the MAPK signaling pathway in microglia.
Abstract
Neuroinflammation‐induced cognitive impairment is characterized by a continued decline in memory, executive functioning, and information‐processing abilities. Although berberine (BBR) exhibits anti‐inflammatory and neuroprotective properties, its ability to mitigate cognitive deficits by regulating microglial‐mediated neuroinflammation remains incompletely understood. To investigate the potential of BBR in mitigating microglial‐mediated neuroinflammation and its detrimental effects on neuroplasticity and spatial memory, a mouse model was established through intrahippocampal microinjection of lipopolysaccharide (LPS). The results showed that BBR pretreatment significantly improved cognitive performance, suppressed microglial activation, reduced hippocampal neuronal damage, and increased the density of functional dendritic spines. Mechanistic analysis revealed that BBR treatment inhibited…
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Taxonomy
TopicsBerberine and alkaloids research · Neuroinflammation and Neurodegeneration Mechanisms · Alkaloids: synthesis and pharmacology