# Burn Selection: How Fire Injury Shaped Human Evolution

## TL;DR

Humans and their ancestors faced unique risks of burn injuries from fire use, which may have driven genetic adaptations in wound healing and inflammation.

## Contribution

The Burn Selection Hypothesis introduces burn injury as a novel evolutionary pressure specific to humans.

## Key findings

- Genes related to burn injury response show signs of accelerated evolution in humans.
- Burns are proposed as a selective force shaping human adaptations and maladaptive responses to injury.
- The hypothesis reframes fire mastery as both a benefit and a cost in human evolution.

## Abstract

The mastery of fire transformed human evolution through advantages spanning diet, behavior, physiology, and ecology. While these benefits are well established, here we highlight a previously overlooked cost — and selective pressure — unique to humans: high‐temperature burn injury. Unlike other species, humans and their hominin ancestors have faced increased lifetime risk of burns, which we argue has driven genetic adaptation. Drawing on comparative genomic evidence across primates, we suggest that genes associated with burn injury response — relating to wound healing and inflammation — show signs of accelerated evolution in humans. We propose that recurrent exposure to burns acted as a selective force in our lineage, helping to explain both beneficial adaptations and paradoxical maladaptive responses to severe injury. By framing burns as an evolutionary pressure, the Burn Selection Hypothesis invites a re‐evaluation of how fire shaped human biology and offers new perspectives for understanding both the evolutionary past and modern burn care.

Intentional fire use exposed humans and their ancestors to high‐temperature burn injury, a risk rare in other species, bringing major survival benefits and technologies but also repeated exposure to extreme heat. The Burn Selection Hypothesis reframes this cost of fire mastery as a unique selective pressure, which shaped our evolution.