# A Strong Supporter: Evidence for the Role of the Fifth Finger in Habitual Gripping Activity

**Authors:** Cora Leder, Sarah A. Schrader

PMC · DOI: 10.1002/ajpa.70205 · 2026-02-04

## TL;DR

This study shows that the fifth finger works with the thumb to support and stabilize gripping activities, using hand bone analysis from historical human remains.

## Contribution

The study reveals the functional role of the fifth finger in habitual gripping through size-adjusted VERA analysis of hand bones.

## Key findings

- The ODM muscle clusters with thumb muscles used in precision grasping, showing habitual coordination.
- The PI3 muscle forms an independent axis of variation with weak correlations to other entheses.
- The fifth finger stabilizes and supports both precision and power grips through thumb opposition and MCP flexion.

## Abstract

The fifth finger plays a key role in manual dexterity, yet its habitual use and functional integration within the hand remain poorly understood. This study investigates the contribution of the fifth ray to habitual gripping activities and its synergistic relationship with the thumb.

The “Validated Entheses‐based Reconstruction of Activity” (VERA) method and multivariate statistical analyses were applied to the hand bones of 43 adult male/probable male individuals from three post‐Medieval skeletal collections in the Netherlands. Principal component and pairwise correlation analyses were used to assess covariation among entheseal attachment sites, with particular focus on the opponens digiti minimi (ODM) and third palmar interosseous (PI3).

Both analyses reproduced functional patterns established in previous VERA studies that distinguish precision from power gripping. The ODM clustered with thumb muscles involved in precision grasping, especially the opponens pollicis (OP), suggesting habitual coordination between the fifth finger and thumb. In contrast, the PI3 formed an independent axis of variation and showed weak correlations with other entheses once overall size effects were removed.

The findings indicate that the fifth finger functions as a stabilizing and supportive element across both grip types, contributing to object control and manual stability through its opposition to the thumb and flexion at the MCP joint. This study underscores the functional significance of the fifth ray in habitual manual activity and highlights the value of size‐adjusted VERA analyses for detecting subtle patterns of hand use in past populations.

## Full-text entities

- **Genes:** AOC1 (amine oxidase copper containing 1) [NCBI Gene 26] {aka ABP, ABP1, DAO, DAO1, KAO, KDAO}, PCSK1 (proprotein convertase subtilisin/kexin type 1) [NCBI Gene 5122] {aka BMIQ12, NEC1, PC1, PC1/3, PC3, SPC3}, WDTC1 (WD and tetratricopeptide repeats 1) [NCBI Gene 23038] {aka ADP, DCAF9}, ADM (adrenomedullin) [NCBI Gene 133] {aka AM, PAMP}, PI3 (peptidase inhibitor 3) [NCBI Gene 5266] {aka ESI, SKALP, WAP3, WFDC14, cementoin}
- **Diseases:** traumatic hand injuries (MESH:D006230), death (MESH:D003643), gout (MESH:D006073), rheumatoid arthritis (MESH:D001172), degenerative diseases (MESH:D019636), osteoarthritis (MESH:D010003)
- **Chemicals:** FPB (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12873511/full.md

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Source: https://tomesphere.com/paper/PMC12873511