Impact of two different hesperidin forms loaded on nanoscale modified borate bioglass scaffolds on rat critical-sized calvarial defects
Nada A. Alqiran, A. M. Abdelghany, Samah Fouad, Mohammed E. Grawish, Yousry M. Elhawary, Eman Hany
TL;DR
This study shows that nanoscale hesperidin on modified borate bioglass scaffolds improves bone healing in rats more than microscale hesperidin or scaffolds alone.
Contribution
A novel nanoscale modified borate bioglass scaffold loaded with hesperidin is introduced for enhanced bone regeneration.
Findings
Nanoscale hesperidin-loaded scaffolds showed the greatest defect closure in rat calvarial defects.
Histological analysis revealed increased osteogenic activity and osteopontin reactivity in nanoscale hesperidin groups.
Modified borate bioglass scaffolds alone promoted bone healing compared to controls.
Abstract
Bone defects remain a major clinical challenge because of their limited self-healing capacity. This study aimed primarily to evaluate whether nanoscale modified borate bioglass scaffolds (MBBGS) could enhance the delivery of hesperidin (HPN), an antioxidant flavonoid, to bone defects, and secondarily to compare the osteogenic effects of micro- and nano-sized HPN (mHPN and nHPN) on bone regeneration. Scaffolds were fabricated and fully characterized. Fifty-six healthy male albino rats were anesthetized, and bilateral critical-sized calvarial defects were created. The rats were divided into four groups: control (empty defects), MBBGS alone, MBBGS loaded with mHPN, and MBBGS loaded with nHPN. The animals were euthanized at the end of the 2nd and 6th weeks postoperatively. The skulls were harvested and processed for radiological, histological, and immunohistochemical analyses. Radiographic…
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Taxonomy
TopicsBone Tissue Engineering Materials · Bone Metabolism and Diseases · Bone health and osteoporosis research