# Mucoacinar Carcinoma of the Parotid Gland

**Authors:** Rachel Chang, Alexander Mackinnon, Benjamin J. Greene, Melad N. Dababneh

PMC · DOI: 10.1007/s12105-026-01889-0 · 2026-02-04

## TL;DR

This paper reports a rare case of mucoacinar carcinoma in the parotid gland, highlighting its unique features and molecular profile.

## Contribution

The study adds to the limited literature on mucoacinar carcinoma by detailing its histomorphology, immunophenotype, and molecular characteristics.

## Key findings

- Mucoacinar carcinoma is a rare subtype of mucoepidermoid carcinoma with serous acinar differentiation.
- The case emphasizes the tumor's unique histological and immunophenotypic features.
- Molecular profiling is presented to aid in understanding this rare cancer subtype.

## Abstract

Mucoacinar carcinoma is an exceedingly rare subtype of mucoepidermoid carcinoma with serous acinar differentiation. We present this case to contribute to the limited existing literature, with emphasis on its molecular profile and unique histomorphology and immunophenotype.

## Linked entities

- **Diseases:** mucoepidermoid carcinoma (MONDO:0003036)

## Full-text entities

- **Genes:** S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, mucin [NCBI Gene 100508689], ANO1 (anoctamin 1) [NCBI Gene 55107] {aka DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A}, NR4A3 (nuclear receptor subfamily 4 group A member 3) [NCBI Gene 8013] {aka CHN, CSMF, MINOR, NOR1}, KRT7 (keratin 7) [NCBI Gene 3855] {aka CK7, K2C7, K7, SCL}, MAML2 (mastermind like transcriptional coactivator 2) [NCBI Gene 84441] {aka MAM-3, MAM2, MAM3, MLL-MAML2}, SOX10 (SRY-box transcription factor 10) [NCBI Gene 6663] {aka DOM, PCWH, SOX-10, WS2E, WS4, WS4C}, IL9 (interleukin 9) [NCBI Gene 3578] {aka HP40, IL-9, P40}
- **Diseases:** acinic cell carcinoma (MESH:D018267), salivary gland malignancy (MESH:D012468), cyst (MESH:D003560), Mucoacinar Carcinoma (MESH:D009369), MEC (MESH:D018277)
- **Chemicals:** luminal (MESH:D010634), H&amp;E (MESH:D006371), Mucicarmine (MESH:C029618)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12872998/full.md

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Source: https://tomesphere.com/paper/PMC12872998