# Formulation and Delivery Systems of Cocaine and Methamphetamine Scent Mimics

**Authors:** Silvia T. Mo, Issac C. C. Cheng, H. T. Henry Chan, Kin Yat Tong, Zhengpei Li, Yang Liu, Kelvin S. Y. Leung, Kangning Ren, Catherine H. H. Hor

PMC · DOI: 10.1155/ianc/2222059 · 2026-02-04

## TL;DR

This paper explores using cotton and metal-organic frameworks to deliver safe, drug-like scents for training and education.

## Contribution

The study introduces low-cost, effective delivery systems for narcotic scent mimics using cotton and MOFs.

## Key findings

- Cotton is more effective than MOFs for storing and releasing pseudoscent chemicals.
- The cotton-based system is safe, durable, and inexpensive for pseudoscent delivery.
- The formulation is easy to store and distribute for training and educational purposes.

## Abstract

Narcotic scent mimics, which are chemicals that emit a perceivable scent similar to that of the illicit drug but do not possess the health and addiction risks of the drug, have applications ranging from canine training in law enforcement agencies to antinarcotic public education. However, low‐cost and easily accessible formulation and delivery systems for narcotic scent mimics have thus far been lacking. In this work, we assess the potential of synthetic (metal‐organic framework, MOF) and natural (cotton) materials as carrier and delivery agents for pseudoscent chemicals mimicking cocaine and methamphetamine. Through liquid chromatography‐based analysis, both materials demonstrate capabilities to act as inert absorbents for the scent mimics, with cotton being the more effective material. Cotton material provides a safe, durable and inexpensive medium for pseudoscent storage and release. The pseudoscent delivery systems are easy to formulate, store and distribute, thus enabling widespread use for both specialised training and public educational purposes.

## Linked entities

- **Chemicals:** cocaine (PubChem CID 2826), methamphetamine (PubChem CID 1206)

## Full-text entities

- **Diseases:** addiction (MESH:D019966), Narcotic scent (MESH:D000079524)
- **Chemicals:** metal-organic framework (MESH:D000073396), Methamphetamine (MESH:D008694), Cocaine (MESH:D003042), MOF (MESH:C037042)
- **Species:** Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12872962/full.md

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Source: https://tomesphere.com/paper/PMC12872962