# A case report of myxoma within the right submandibular muscle and a literature review

**Authors:** Dingyu Tian, Xiao Liang, Juntao Ma, Ye Li, Yuliang Zhang, Rui Zhang

PMC · DOI: 10.3389/fsurg.2025.1733176 · 2026-01-22

## TL;DR

This paper reports a rare case of a benign tumor in the submandibular muscle and reviews existing literature on similar cases.

## Contribution

The paper adds a new case of submandibular intramuscular myxoma and highlights its diagnostic challenges.

## Key findings

- Intramuscular myxoma is a rare benign tumor with an incidence of 0.10–0.13 per 100,000 individuals.
- Submandibular myxomas can be misdiagnosed as sublingual gland cysts due to nonspecific symptoms and imaging features.
- Complete surgical excision is the preferred treatment and typically results in a good prognosis.

## Abstract

To investigate the etiology, clinical presentation, management, and prognosis of intramuscular myxoma occurring in the submandibular region.

A case of intramuscular myxoma originating from the mylohyoid muscle was analyzed. The patient's clinical history, imaging features, surgical findings, and pathological results were reviewed. Relevant characteristics were summarized in the context of previously published literature.

The patient presented with a painless mass in the submandibular area. Computed tomography revealed a cystic lesion, and postoperative histopathological examination confirmed the diagnosis of intramuscular myxoma. The patient recovered well following surgical excision.

Intramuscular myxoma is a rare benign soft-tissue tumor, with an estimated incidence of approximately 0.10–0.13 per 100,000 individuals. Lesions arising in the submandibular muscles are exceptionally uncommon and may be misdiagnosed as sublingual gland cysts. Due to the nonspecific clinical manifestations and potential for misdiagnosis on imaging, histopathological evaluation remains the definitive diagnostic method. Complete surgical excision is the treatment of choice and is generally associated with a favorable prognosis.

## Full-text entities

- **Diseases:** tissue tumor (MESH:D009369), Intramuscular myxoma (MESH:D009232), sublingual gland cysts (MESH:D013362), soft (MESH:C562950)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12872867/full.md

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Source: https://tomesphere.com/paper/PMC12872867