# Relationship between lacrimal gland changes and corneal parameters in patients with primary Sjögren’s syndrome and non-Sjögren’s syndrome-related dry eye

## TL;DR

This study explores how changes in the lacrimal gland relate to corneal issues in patients with Sjögren’s syndrome-related dry eye compared to non-Sjögren’s dry eye.

## Contribution

The study introduces a novel multimodal imaging approach to map structural-functional relationships in Sjögren’s syndrome-related dry eye.

## Key findings

- SSDE patients showed increased nerve tortuosity, dendritic cell density, and parenchymal echogenicity compared to NSSDE.
- Lacrimal gland area was an independent risk factor for corneal nerve depletion in dry eye patients.
- Dendritic cell density and activation strongly predicted SSDE with high AUC values.

## Abstract

Primary Sjögren’s syndrome(pSS) is characterized as an autoimmune disorder mostly involving exocrine glands and pSS related dry eye (SSDE) contributes to a severe subtype of dry eye disease (DED). Emerging imaging tools for ocular surface evaluation such as lacrimal gland ultrasonography (LGUS) and in vivo confocal microscopy (IVCM) remain underutilized in diagnosing the SSDE. This study aims to investigate LGUS-IVCM correlations to map structural-functional relationships in SSDE patients.

This prospective cross-sectional study enrolled 27 SSDE patients and 12 non-pSS related dry eye (NSSDE) controls, utilizing IVCM and LGUS to assess corneal nerve morphology, immune cell activity, and glandular structural parameters.

SSDE patients exhibited greater nerve tortuosity (p = 0.003), dendritic cell density (p < 0.001), and parenchymal echogenicity alterations (p = 0.013) versus NSSDE. For dry eye patients, subbasal nerve density inversely correlated with lacrimal gland area (r = −0.352, p < 0.05), logistic regression confirmed lacrimal gland area as an independent risk factor of nerve depletion. Meanwhile, ROC curve of dendritic cell density and activation strongly predicted SSDE with an AUC of 0.838 and 0.827.

SSDE patients experience more corneal epithelial injury, with progressive lacrimal gland changes contributing to corneal nerve damage and inflammation. Multimodal ophthalmic imaging elucidates the interconnected lacrimal gland-corneal neuroimmune dysfunction in SSDE, offering potential diagnostic biomarkers and therapeutic targets for future exploration.