# The Critical Importance of Recognizing De Winter's T-wave Pattern: A Case of Acute Proximal LAD Occlusion by In-Stent Restenosis

**Authors:** Hsiao Chin-Yuan, Wu Keng-Yi

PMC · DOI: 10.7759/cureus.102984 · 2026-02-04

## TL;DR

A case shows how recognizing De Winter's T-wave pattern on an ECG is crucial for timely treatment of a severe heart condition.

## Contribution

This case emphasizes the urgent need to identify De Winter's T-wave pattern to prevent delays in reperfusion therapy.

## Key findings

- De Winter's T-wave pattern was identified in a patient with acute LAD occlusion due to in-stent restenosis.
- The patient's condition improved after urgent treatment with a drug-coating balloon.
- High-sensitivity troponin I levels indicated significant cardiac damage.

## Abstract

De Winter's T-wave pattern is a high-risk ST-elevation myocardial infarction (STEMI) equivalent signifying acute proximal left anterior descending (LAD) occlusion, characterized by precordial upsloping ST-depression and tall, peaked T-waves. We present a 69-year-old man with chest pain whose electrocardiogram (ECG) showed a classic De Winter's pattern. He rapidly developed acute respiratory failure, and his high-sensitivity troponin I peaked at >27,027 pg/mL. Urgent angiography identified severe in-stent restenosis (ISR) in the proximal-mid LAD as the culprit lesion. This was successfully treated with a drug-coating balloon. This case highlights that De Winter's pattern is a critical finding that must be immediately recognized to prevent delays in emergent reperfusion therapy.

## Linked entities

- **Diseases:** ST-elevation myocardial infarction (MONDO:0041656)

## Full-text entities

- **Diseases:** STEMI (MESH:D000072657), acute respiratory failure (MESH:D012131), -stent restenosis (MESH:D023903), chest pain (MESH:D002637), proximal left anterior descending (LAD) occlusion (MESH:D000094629), myocardial infarction (MESH:D009203)

## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12872277/full.md

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Source: https://tomesphere.com/paper/PMC12872277