Effect of morphology on the biomechanics of contusion models of non-human primate spinal cord injury: a finite element study in a digital population
Numaira Obaid, Dexter L. Zamora, Cesar Jimenez-Gonzalez, Carolyn J. Sparrey
TL;DR
This study shows how spinal cord injury outcomes in non-human primates vary due to morphological differences, using finite element models to highlight the need for diverse computational models.
Contribution
The novelty lies in demonstrating the effect of morphological variability on biomechanical outcomes in spinal cord injury models using a digital population.
Findings
Morphological differences significantly affect peak forces during spinal cord injury simulations.
Variability in impact forces can lead to different functional outcomes, from no deficits to contralateral contusions.
Peak forces are statistically correlated with white matter sparing, influencing functional recovery.
Abstract
Traumatic spinal cord injuries (SCIs) stem from mechanical events that translate external forces through the spinal column, damaging the spinal cord. Since tissue damage is related to the strain/stress it experiences, finite element models are being increasingly used to supplement pre-clinical models of animal SCI. Simulations; however, are often conducted in a single geometry, while morphological variability has been highlighted as having an important influence on biomechanical outcomes. We developed tissue scale finite element models of non-human primate spinal cord injury with different morphologies (N = 40) to assess the effect of morphology on biomechanical outcomes. Applying the same displacement to different digital subjects generated different peak forces, and the magnitude of these forces was related to subject morphology, specifically the area of cerebrospinal fluid (CSF) and…
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Taxonomy
TopicsSpinal Cord Injury Research · Cervical and Thoracic Myelopathy · Automotive and Human Injury Biomechanics