Optoacoustically augmented magnetic guidewire for radiation-free minimally invasive therapies
Fan Wang, Xianqiang Bao, Erdost Yildiz, Yan Yu, Xosé Luís Deán-Ben, Wenbin Kang, Shuaizhong Zhang, Devin Sheehan, Ren Hao Soon, Jelena Zinnanti, Daniel Razansky, Metin Sitti
TL;DR
A new guidewire combines magnetic navigation and optoacoustic imaging to enable radiation-free, targeted therapies for cerebrovascular diseases.
Contribution
A multifunctional guidewire integrating optoacoustic imaging and magnetic navigation for radiation-free, image-guided interventions.
Findings
OptoMaG can be actively navigated with external magnetic fields to reach target brain sites in a 3D cerebrovascular phantom.
The FePt tip allows localized thermal ablation and photodynamic therapy for tumor treatment without radiation.
The guidewire serves as a radiation-free platform for real-time navigation and targeted therapies.
Abstract
Endovascular interventions are essential for treating cerebrovascular diseases, yet their monitoring methods commonly rely on ionizing radiation and contrast agents, posing unnecessary risks to patients and clinicians. We present a multifunctional optoacoustically augmented magnetic guidewire (OptoMaG) that integrates optoacoustic imaging with magnetic navigation to enable radiation-free, image-guided interventions. The ~250-micrometer flexible guidewire incorporates a 460-nanometer luminescent core with an enhanced optoacoustic signature and a FePt magnetic tip for precise, steerable control. Proof-of-concept studies show that OptoMaG can be actively navigated with external magnetic fields to traverse a 3D human-scale cerebrovascular phantom and accurately reach target brain sites. Beyond navigation, the FePt tip enables localized thermal ablation under remote radiofrequency…
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Taxonomy
TopicsPhotoacoustic and Ultrasonic Imaging · Micro and Nano Robotics · Nanoplatforms for cancer theranostics