Exploring the basis of Traditional Chinese Medicine in treating cardiovascular disease: insights into the microbiota-gut-heart axis

TL;DR

This paper explores how Traditional Chinese Medicine affects cardiovascular disease through interactions with the gut microbiome, offering new insights for personalized treatments.

Contribution

The paper provides a novel perspective on the microbiota-gut-heart axis in TCM for cardiovascular disease.

Findings

Gut microbiota influences the bioavailability and efficacy of TCM.

TCM can alter gut microbial composition and function, impacting cardiovascular health.

Microbial metabolites are closely linked to the onset and progression of CVD.

Abstract

Despite being widely used to treat cardiovascular disease (CVD), there are still limitations of Traditional Chinese Medicine (TCM) for their widespread use due to undetermined pharmacological mechanisms. The emerging area of “pharmacomicrobiology” facilitates the pursuing of the complex interactions between TCM and gut microbiome as the gut microbiota influences TCM bioavailability and efficacy, vice versa TCM affects the microbial composition and function. Furthermore, research over the past decades has proved that gut dysbiosis and diverse microbial metabolites intimately related to the onset and progression of CVD. Herein, we summarize latest understanding of the TCM–gut–heart axis in CVD, with an emphasis on describing microbial changes and the associated mechanisms in CVD, elaborating the role of gut microbiota in metabolizing TCM, and how TCM can be used to treat CVD through affecting the gut microbiota. We further highlight the challenges and future directions that target TCM–gut–heart axis in prospects for personalized medicine in CVD, thus to present novel insights for developing new therapeutic approaches.

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