Winners take it all: turning cell competition into a therapeutic ally
Tereza Fantová, Maxima Warmuzová, Sandra Charvátová, Kateřina Stošková, Tomáš Jelínek, Michal Šimíček, Roman Hájek, Juli R. Bagó
TL;DR
Cell competition, where healthy cells eliminate unhealthy ones, could lead to new treatments for diseases like cancer.
Contribution
The paper categorizes therapeutic opportunities based on the physiological settings of cell competition.
Findings
Cell competition acts as a natural quality control mechanism eliminating unfit or malignant cells.
Cancer cells can exploit cell competition to promote tumor growth.
Understanding context-dependent mechanisms opens new therapeutic possibilities.
Abstract
Recent discoveries in the field of cell competition have brought this phenomenon into the spotlight due to its potential to inspire novel therapeutic approaches for previously incurable diseases. Cell competition, a process observed across multicellular organisms, acts as a natural quality control mechanism in which unfit, abnormal, or malignant cells are actively eliminated by neighboring, healthy-fit cells. However, the mechanisms and outcomes of cell competition are highly context-dependent, influenced by the environment, developmental stage, and specific tissue involved. Emerging research also highlights a darker aspect where cancer cells can hijack cell competition to their advantage, promoting tumor growth and progression. A deeper understanding of cell competition opens up a wide range of therapeutic possibilities for diseases that currently lack effective treatments. Given its…
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Taxonomy
TopicsHippo pathway signaling and YAP/TAZ · Phagocytosis and Immune Regulation · Cancer Cells and Metastasis