Experimental plasmonic sensing of malaria using an aluminum metasurface
Amos Sospeter Kiyumbi, Mark Simon Tame
TL;DR
Researchers developed a new optical biosensor using aluminum nanoholes to detect a malaria biomarker with high sensitivity and low cost.
Contribution
A novel aluminum metasurface-based biosensor for label-free detection of pfLDH in the visible spectrum is introduced.
Findings
The biosensor achieves a spectral sensitivity of 360 nm per RIU.
The limit of detection is 1.3 nM (45.6 ng mL−1) for pfLDH.
The sensor operates in the visible range and is suitable for label-free malaria diagnosis.
Abstract
A wide range of methods currently exist for testing the presence of malaria, each with its own advantages and disadvantages. New technologies are urgently needed to develop more effective diagnosis tools to fight and eradicate malaria. Optical biosensors that employ surface plasmon resonance (SPR) techniques are a promising category of devices for detecting malaria biomarkers. One such biomarker is plasmodium lactate dehydrogenase (pLDH), a protein produced during the life cycle of the malaria parasite, which is a metabolic enzyme found in all plasmodium species, including the most widespread falciparum. This work reports on the design, probing, and experimental performance of an optical biosensor for detecting pLDH based on SPR and extraordinary optical transmission. The biosensor is composed of an aluminum metasurface made from an array of nanoholes. The sensor operates in the visible…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
Click any figure to enlarge with its caption.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Figure 10
Figure 11
Figure 12
Figure 13
Figure 14
Figure 15
Figure 16
Figure 17
Figure 18
Figure 19
Figure 20
Figure 21
Figure 22
Figure 23
Figure 24Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsPlasmonic and Surface Plasmon Research · Metamaterials and Metasurfaces Applications · Gold and Silver Nanoparticles Synthesis and Applications