# Mycobacterium decipiens Infection in Patient Receiving Anti–TNF-α Therapy, France, 2024

**Authors:** Justin Charles-Antoine Destoop, Corentin Poignon, William Danjou, Alexandre Bleibtreu, Valerie Pourcher, Gentiane Monsel

PMC · DOI: 10.3201/eid3201.250518 · Emerging Infectious Diseases · 2026-01-01

## TL;DR

A patient in France with inflammatory bowel disease developed a skin infection from Mycobacterium decipiens, a new species related to tuberculosis, and was successfully treated with oral antibiotics.

## Contribution

This is the first reported case of M. decipiens infection in a patient receiving anti–TNF-α therapy.

## Key findings

- M. decipiens infection occurred in a patient on anti–TNF-α therapy for inflammatory bowel disease.
- The infection was successfully treated with an oral antimicrobial regimen.
- M. decipiens shows high genomic similarity to M. tuberculosis.

## Abstract

Mycobacterium decipiens is a newly identified species with high genomic similarity to M. tuberculosis. We report a cutaneous M. decipiens infection in a patient in France who had inflammatory bowel disease being treated with anti–tumor necrosis factor-α therapy. The infection was successfully treated with an oral antimicrobial regimen.

## Linked entities

- **Diseases:** inflammatory bowel disease (MONDO:0005265)
- **Species:** Mycobacterium decipiens (taxon 1430326)

## Full-text entities

- **Genes:** TNF (tumor necrosis factor) [NCBI Gene 7124] {aka DIF, IMD127, TNF-alpha, TNFA, TNFSF2, TNLG1F}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}
- **Diseases:** fever (MESH:D005334), MDR (MESH:D018088), skin lesions (MESH:D012871), necrosis (MESH:D009336), tendinopathy (MESH:D052256), inflammation (MESH:D007249), lymphadenopathy (MESH:D008206), irritable bowel disease (MESH:D043183), Mycobacterium decipiens Infection (MESH:D009164), depressed (MESH:D003866), weight loss (MESH:D015431), bursitis (MESH:D002062), M. decipiens infection (MESH:C566367), trauma (MESH:D014947), granulomas (MESH:D006099), inflammatory bowel disease (MESH:D015212), Cutaneous infection (MESH:D007239), erythematous papule (MESH:D000169), pigmented macular lesions (MESH:D008268)
- **Chemicals:** ethambutol (MESH:D004977), rifabutin (MESH:D017828), moxifloxacin (MESH:D000077266), adalimumab (MESH:D000068879), rifampin (MESH:D012293), Anti (-), linezolid (MESH:D000069349), trimethoprim/sulfamethoxazole (MESH:D015662), mesalazine (MESH:D019804), isoniazid (MESH:D007538), amikacin (MESH:D000583), macrolide (MESH:D018942), clarithromycin (MESH:D017291)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mycobacterium tuberculosis (species) [taxon 1773], Mycobacterium kansasii (species) [taxon 1768], Mycobacterium intracellulare (species) [taxon 1767], Mycobacterium tuberculosis complex (species group) [taxon 77643], Mycobacterium szulgai (species) [taxon 1787], Mycobacterium avium (species) [taxon 1764], Mycobacterium decipiens (species) [taxon 1430326], Human immunodeficiency virus 1 (no rank) [taxon 11676], Decipisagitta decipiens (species) [taxon 366427]
- **Mutations:** C-35 C

## Full text

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## Figures

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## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12870094/full.md

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Source: https://tomesphere.com/paper/PMC12870094