# Evidence of Rat Hepatitis E Virus Circulation through Wastewater Surveillance, Central Argentina **Authors:** Bianca Filoni, María Emilia Lucero, Guadalupe Di Cola, Anabella Fantilli, Alfonsina Roccia, Paola Sicilia, Liliana Luque, Ariana Cachi, María de los Ángeles Marinzalda, Gonzalo Castro, Gisela Masachessi, Viviana Ré, María Belén Pisano PMC · DOI: 10.3201/eid3201.251218 · Emerging Infectious Diseases · 2026-01-01 ## TL;DR Rat hepatitis E virus was detected in most wastewater samples in central Argentina, suggesting its presence in the region and the need for further study. ## Contribution This study provides the first evidence of rat hepatitis E virus circulation in central Argentina through wastewater surveillance. ## Key findings - Rat hepatitis E virus was detected in 67.7% of wastewater samples from central Argentina. - The findings highlight the need to investigate the virus in animal reservoirs and humans, particularly in cases of unknown hepatitis. ## Abstract During 2023–2024, we detected rat hepatitis E virus in 67.7% of wastewater samples from central Argentina. This high level of detection opens new inquiries in the region, highlighting the need to investigate the virus in both animal reservoirs and humans, with a focus on hepatitis cases of unknown etiology. ## Linked entities - **Diseases:** hepatitis (MONDO:0002251) ## Full-text entities - **Diseases:** infection (MESH:D007239), hepatitis (MESH:D056486), death (MESH:D003643), viral hepatitis (MESH:D014777) - **Chemicals:** water (MESH:D014867), oligonucleotide (MESH:D009841), polyethylene glycol-6000 (MESH:C000595215) - **Species:** hepatitis E virus [taxon 12461], Homo sapiens (human, species) [taxon 9606], Sus scrofa (pig, species) [taxon 9823], Rattus norvegicus (brown rat, species) [taxon 10116] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12870092/full.md ## Figures 2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12870092/full.md ## References 15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12870092/full.md --- Source: https://tomesphere.com/paper/PMC12870092