# Emerging Respiratory Virus Threats from Influenza D and Canine Coronavirus HuPn-2018

**Authors:** Gregory C. Gray, Anastasia N. Vlasova, John A. Lednicky, Thang Nguyen-Tien, Ismaila Shittu, Feng Li

PMC · DOI: 10.3201/eid3201.251764 · Emerging Infectious Diseases · 2026-01-01

## TL;DR

Two new respiratory viruses, influenza D and canine coronavirus HuPn-2018, are emerging threats with potential to cause human epidemics.

## Contribution

Highlights the urgent need for diagnostics and surveillance for newly recognized respiratory viruses.

## Key findings

- Influenza D and canine coronavirus HuPn-2018 have significant potential to cause human epidemics.
- Current diagnostics and surveillance for these viruses are lacking.
- Little action is being taken to prevent or respond to diseases caused by these viruses.

## Abstract

In 2009 and again in 2019, public health warnings were confirmed by the emergence, rapid widespread transmission, and lethality of novel influenza and coronaviruses. The world continues to suffer disease from these respiratory viruses. Two newly recognized emergent respiratory viruses, influenza D and canine coronavirus HuPn-2018, have been shown to have considerable potential for causing future human epidemics, but diagnostics and surveillance for the viruses are lacking. We reviewed data regarding influenza D virus and coronavirus canine coronavirus HuPn-2018. Those data strongly indicate that these viruses are major newly recognized threats. However, little is being done to respond to or prevent disease associated with these viruses, warranting the question of whether we will learn from previous pandemics.

## Full-text entities

- **Genes:** ANPEP (alanyl aminopeptidase, membrane) [NCBI Gene 290] {aka AP-M, AP-N, APN, CD13, GP150, LAP1}
- **Diseases:** cancer (MESH:D009369), infection (MESH:D007239), pneumonia (MESH:D011014), disease (MESH:D004194), respiratory disease (MESH:D012140), death (MESH:D003643), emergencies (MESH:D004630), covid19 (MESH:D000086382), IDV (MESH:D007251)
- **Species:** Coronaviridae (family) [taxon 11118], Canine coronavirus (no rank) [taxon 11153], Middle East respiratory syndrome-related coronavirus (no rank) [taxon 1335626], Giraffa camelopardalis (giraffe, species) [taxon 9894], Canis lupus familiaris (dog, subspecies) [taxon 9615], Feline coronavirus (no rank) [taxon 12663], Severe acute respiratory syndrome-related coronavirus (no rank) [taxon 694009], Alphacoronavirus (genus) [taxon 693996], Orthomyxoviridae (family) [taxon 11308], Adenoviridae (family) [taxon 10508], Deltainfluenzavirus (genus) [taxon 1511083], Bacillus sp. AT (species) [taxon 1196779], Cavia porcellus (domestic guinea pig, species) [taxon 10141], H5N1 subtype (serotype) [taxon 102793], Influenza D virus (no rank) [taxon 1511084], Homo sapiens (human, species) [taxon 9606], Sus scrofa (pig, species) [taxon 9823], Mus musculus (house mouse, species) [taxon 10090], Mustela putorius furo (black ferret, subspecies) [taxon 9669], Canine coronavirus 2 (no rank) [taxon 2185079], Viruses (acellular root) [taxon 10239], Influenza C virus (no rank) [taxon 11552], Gammacoronavirus (genus) [taxon 694013], Bos taurus (bovine, species) [taxon 9913], Transmissible gastroenteritis virus (no rank) [taxon 11149]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12870013/full.md

## References

49 references — full list in the complete paper: https://tomesphere.com/paper/PMC12870013/full.md

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Source: https://tomesphere.com/paper/PMC12870013