# Fluorinated terpenoids and their fluorine-containing derivatives

## TL;DR

This paper reviews methods to create fluorinated terpenoids, which are important for pharmaceutical development due to their unique properties.

## Contribution

The paper provides a comprehensive review of synthetic strategies for fluorinating various terpenoid subclasses.

## Key findings

- Fluorinated terpenoids exhibit enhanced or diversified bioactivity profiles.
- Synthetic methods for fluorinating terpenoids have been successfully developed.
- Fluorinated terpenoids are gaining importance in pharmaceutical chemistry.

## Abstract

Fluorine-containing molecules have attracted increasing attention in pharmaceutical chemistry owing to their unique physicochemical properties. As there are no known examples of naturally occurring fluorinated organic molecules, fluorination of organic molecules gains significant interest in organic synthesis. Terpenoids represent one of the largest and most structurally diverse classes of natural products, exhibiting a broad range of pharmacological effects. Fluorination of terpenoid scaffolds has therefore become an active area of research aimed at enhancing or diversifying their bioactivity profiles. This review summarizes the synthetic strategies developed for the preparation of fluorinated terpenoids across different subclasses, including mono-, sesqui-, di-, tri-, and tetranor-terpenes.

Synthetic methods for the fluorination of terpenoids have enabled the development of fluorinated terpenoids as important pharmaceuticals.