# Partial Freezing Enables Functional Preservation of Kidney Grafts for up to 10 Days

**Authors:** Korkut Uygun, McLean Taggart, Madeeha Hassan, Arnaud Lyon, O. Sila Ozgur, Christopher Taveras, Mohammadreza Mojoudi, Thomas Agius, Sophie Van Tulder, Christina Zheng, Michael Macarthur, James Markmann, Heidi Yeh, Shannon Tessier, Mehmet Toner, Alban Longchamp

PMC · DOI: 10.21203/rs.3.rs-7820837/v1 · Research Square · 2026-01-14

## TL;DR

This paper shows that partially freezing kidneys can preserve their function for up to 10 days, better than traditional methods.

## Contribution

The novel approach of partial freezing extends kidney graft viability for longer storage and transport.

## Key findings

- Partially frozen kidneys showed improved function after 10 days of storage.
- Swine and human kidneys were successfully preserved using this method.
- Function was assessed via simulated transplantation protocols.

## Abstract

Kidney transplantation is critically limited by the shortage of available donor organs, exacerbated by the discarding of viable organs due to insufficient allocation time. Here, we demonstrate the application of nature-inspired partial freezing for long-term storage of kidney grafts. We show that, after 10 days of storage, partially frozen swine and human kidneys retain improved function compared to those preserved using traditional static cold storage, as assessed via simulated transplantation.

## Linked entities

- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Species:** Homo sapiens (human, species) [taxon 9606], Sus scrofa (pig, species) [taxon 9823]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12869680/full.md

## References

39 references — full list in the complete paper: https://tomesphere.com/paper/PMC12869680/full.md

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Source: https://tomesphere.com/paper/PMC12869680