# First person – Mrudula Dileep and Anamika Sharma

## TL;DR

This paper discusses research on Parkinson's disease, focusing on mitochondrial oxidative stress and the roles of IP3R and Parkin mutants.

## Contribution

The study identifies mitochondrial oxidative stress as an early feature of Parkinson's disease through the synergism of IP3R and Parkin mutants.

## Key findings

- Mitochondrial oxidative stress is an early feature of Parkinson's disease.
- The synergism of IP3R and Parkin mutants contributes to this oxidative stress.
- The findings suggest new insights into the pathogenesis of Parkinson's disease.

## Abstract

First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping researchers promote themselves alongside their papers. Mrudula Dileep and Anamika Sharma are co-first authors on ‘
Synergism of IP3R and Parkin mutants identifies mitochondrial oxidative stress as an early feature of Parkinson's disease’, published in DMM. Mrudula conducted the research described in the article while a project associate in the lab of Professor Gaiti Hasan at National Centre for Biological Sciences, Bengaluru, India, and is now a PhD student in Jacek Kuźnicki's lab at International Institute of Molecular and Cellular Biology (IIMCB), Warsaw, Poland, investigating calcium-iron homeostasis in zebrafish models of Parkinson's disease. Anamika conducted the research described in the article while a PhD student in the lab of Professor Gaiti Hasan at National Centre for Biological Sciences, Bengaluru, India, and is now a postdoctoral associate in Professor Stuart Lipton's lab at The Scripps Research Institute, La Jolla, CA, USA, investigating how lifestyle and environmental factors modulate cellular and molecular functions in the brain to influence neurological health and disease.