# Cost-effectiveness of multimodal intervention for the prevention of dementia in Japan

## TL;DR

A study in Japan found that a multimodal intervention for preventing dementia is cost-effective and improves quality of life for older adults with mild cognitive impairment.

## Contribution

The study demonstrates that the J-MINT intervention is cost-saving and effective in improving quality of life for individuals with mild cognitive impairment.

## Key findings

- J-MINT was projected to save JPY 452,826 per person over 35 years and gain 0.08 QALYs.
- The intervention was dominant compared to usual care, showing cost savings and effectiveness.
- Targeting APOE ε4 carriers or individuals with high exercise adherence increased benefits.

## Abstract

This analysis evaluated the potential cost-effectiveness of the Japan-Multimodal Intervention Trial for the prevention of dementia (J-MINT), targeting older adults with mild cognitive impairment (MCI) from a societal perspective.

Using a time-dependent cohort state-transition model, we estimated the long-term economic impact of J-MINT. Costs included medical, long-term, and informal care. Incremental cost-effectiveness ratios (ICERs) were calculated based on simulated costs and quality-adjusted life years (QALYs).

The base-case analysis indicated that the J-MINT was dominant, demonstrating cost saving and more effective compared to usual care. Over 35 years, J-MINT was projected to achieve cost savings of JPY 452,826 per person and a gain of 0.08 QALYs. Deterministic and probabilistic sensitivity analyses confirmed the robustness of these findings. Scenario analysis suggested that targeting APOE ε4 carriers or individuals with high adherence to exercise yielded even greater benefits.

J-MINT demonstrates cost-effectiveness by reducing overall care costs while improving QALYs in individuals with MCI.