# A Giant Cervical Decidual Polyp in Pregnancy Managed With Lactoferrin, Probiotics, and Ligation: A Case Report

## TL;DR

A pregnant woman with a large cervical polyp was successfully treated with lactoferrin, probiotics, and ligation, avoiding antibiotics and ensuring a healthy pregnancy outcome.

## Contribution

A novel minimally invasive treatment combining ligation and probiotics for cervical polyps in pregnancy is proposed.

## Key findings

- Polyp ligation with lactoferrin and probiotics led to polyp necrosis and resolution.
- Vaginal Lactobacillus spp. increased and cervicitis resolved without antibiotics.
- The patient delivered a healthy infant at full term.

## Abstract

Giant cervical decidual polyps during pregnancy increase the risk of miscarriage and preterm delivery; however, optimal management has not yet been established. We report the case of a pregnant woman who presented at 11 weeks of gestation with a bleeding 4‐cm cervical polyp. Oral lactoferrin and probiotics (
Clostridium butyricum
,
Enterococcus faecium
, and
Bacillus subtilis
) were administered. The polyp stalk near the external cervical os was ligated with triclosan‐coated polydioxanone, resulting in necrosis and removal at 13 weeks, with complete resolution by 14 weeks. Vaginal Lactobacillus spp. increased and cervicitis resolved by 20 weeks without the use of antibiotics, despite the presence of Ureaplasma and/or Mycoplasma in vaginal secretions. The patient delivered a healthy infant at 40 weeks. This case highlights a minimally invasive strategy—polyp ligation combined with lactoferrin and probiotics—to help restore vaginal homeostasis, avoid the use of antibiotics, and achieve a favorable pregnancy outcome.

A minimally invasive approach combining cervical polyp ligation with oral lactoferrin and lactic acid–producing probiotics may help restore vaginal homeostasis and limit ascending infection in early pregnancy. This strategy may reduce the risk of spontaneous miscarriage or preterm delivery in patients with large decidual polyps while avoiding antibiotic use.