# Extra-helical allosteric binding site of apomorphine in ADGRG6

**Authors:** Na Qiu, Wei Xu, Tuo Xu, Wenbin Xie, Youqi Jiang, Zhiwei Zhong, Limin Ma, Qiang Zhao, Beili Wu, Shuo Han

PMC · DOI: 10.1038/s41421-025-00866-1 · Cell Discovery · 2026-02-03

## Full-text entities

- **Genes:** ADGRG5 (adhesion G protein-coupled receptor G5) [NCBI Gene 221188] {aka GPR114, PGR27}, GALNS (galactosamine (N-acetyl)-6-sulfatase) [NCBI Gene 2588] {aka GALNAC6S, GAS, GalN6S, MPS4A}, ADGRL3 (adhesion G protein-coupled receptor L3) [NCBI Gene 23284] {aka CIRL3, CL3, LEC3, LPHN3}, ADGRD1 (adhesion G protein-coupled receptor D1) [NCBI Gene 283383] {aka GPR133, PGR25}, ADGRF1 (adhesion G protein-coupled receptor F1) [NCBI Gene 266977] {aka GPR110, KPG_012, PGR19, hGPCR36}, ADGRG1 (adhesion G protein-coupled receptor G1) [NCBI Gene 9289] {aka BFPP, BPPR, CDCBM14B, CDCBM15A, GPR56, TM7LN4}, ADGRG2 (adhesion G protein-coupled receptor G2) [NCBI Gene 10149] {aka CBAVDX, EDDM6, GPR64, HE6, TM7LN2}, ADGRE5 (adhesion G protein-coupled receptor E5) [NCBI Gene 976] {aka CD97, TM7LN1}, ADGRG4 (adhesion G protein-coupled receptor G4) [NCBI Gene 139378] {aka GPR112, PGR17, RP1-299I16}, ADGRG6 (adhesion G protein-coupled receptor G6) [NCBI Gene 57211] {aka APG1, DREG, GPR126, LCCS9, PR126, PS1TP2}, GPR166P (G protein-coupled receptor 166, pseudogene) [NCBI Gene 442206] {aka GPCR, PGR9}, SUCLG2 (succinate-CoA ligase GDP-forming subunit beta) [NCBI Gene 8801] {aka G-SCS, GBETA, GTPSCS}, CXCR6 (C-X-C motif chemokine receptor 6) [NCBI Gene 10663] {aka BONZO, CD186, CDw186, STRL33, TYMSTR}
- **Diseases:** scoliosis (MESH:D012600), demyelinating diseases (MESH:D003711), ADGRs (MESH:D004314), breast cancer (MESH:D001943), congenital contractures (MESH:D003286)
- **Chemicals:** Stalk peptide (-), Apomorphine (MESH:D001058), catechol (MESH:C034221), glaucine (MESH:C005004)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** proline residue is replaced by cysteine, glutamine is substituted by tyrosine
- **Cell lines:** S2 — Drosophila melanogaster (Fruit fly), Spontaneously immortalized cell line (CVCL_Z232), High Five — Trichoplusia ni (Cabbage looper), Spontaneously immortalized cell line (CVCL_C190)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12868696/full.md

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12868696/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC12868696/full.md

---
Source: https://tomesphere.com/paper/PMC12868696