# Three new 14-noreudesmane-type sesquiterpenoids from the roots of Hippophae rhamnoides

## TL;DR

This study discovers three new sesquiterpenoids from sea buckthorn roots but finds they lack significant biological activity.

## Contribution

The discovery of three new 14-noreudesmane-type sesquiterpenoids from Hippophae rhamnoides roots expands its chemical profile.

## Key findings

- Three new 14-noreudesmane-type sesquiterpenoids (1–3) were isolated from H. rhamnoides roots.
- The new compounds showed no significant antioxidant, anti-inflammatory, antibacterial, or α-glucosidase inhibitory activity.
- Known pentacyclic triterpenoids from the roots displayed α-glucosidase inhibitory and antibacterial activities.

## Abstract

Hippophae rhamnoides L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of three new 14-noreudesmane-type sesquiterpenoids (1–3), together with sixteen known compounds (4–19). Their structures and absolute configurations were determined using comprehensive spectroscopic analyses and quantum chemical computations of electronic circular dichroism (ECD) spectra and 13C NMR shifts. Three new sesquiterpenoids (1–3) were tested for their antioxidant, anti-inflammatory, antibacterial, and α-glucosidase inhibitory activities. Unfortunately, none exhibited significant activity under the tested conditions. Among the isolated known compounds, all those displaying α-glucosidase inhibitory and antibacterial activities are pentacyclic triterpenoids. Hippophamide (17) showed significant DPPH and ABTS radical-scavenging activity. These results enriched the chemical profile of H. rhamnoides roots.

The online version contains supplementary material available at 10.1007/s13659-025-00581-0.