# Fluorescence molecular imaging technology: a promising new strategy for the diagnosis and treatment of gynecologic tumors

**Authors:** Kailang Li, Bifan Huang, Jin Jiang

PMC · DOI: 10.3389/fbioe.2025.1774573 · Frontiers in Bioengineering and Biotechnology · 2026-01-21

## TL;DR

Fluorescence molecular imaging is a promising technique for improving the diagnosis and treatment of gynecologic tumors by enabling precise visualization during surgery.

## Contribution

The paper reviews recent advances in fluorescence imaging technology and its application in gynecologic oncology.

## Key findings

- Fluorescence imaging offers high sensitivity and spatial resolution for tumor detection.
- Tumor-specific molecular probes enhance surgical accuracy and therapeutic outcomes.
- The technology supports real-time intraoperative navigation and visualization of tumor features.

## Abstract

Gynecologic malignancies such as ovarian, endometrial, and cervical cancers are characterized by challenges in early diagnosis and high therapeutic complexity, creating an urgent need for more precise imaging techniques. Fluorescence molecular imaging, a modality with high sensitivity and high spatial resolution, has demonstrated considerable value in tumor diagnosis and therapy in recent years. Its application in gynecologic oncology is rapidly expanding. By using tumor-specific molecular probes to label neoplastic tissues, this technology enables real-time intraoperative navigation and visualization of tumor lesions and their local features, thereby significantly improving surgical accuracy and therapeutic outcomes. This review summarizes the basic principles of fluorescence imaging, recent advances in molecular probe design, and developments in imaging devices. It places particular emphasis on the value of fluorescence molecular imaging in the diagnosis and precision treatment of gynecologic tumors, aiming to provide systematic theoretical guidance and technical support for related research and clinical practice.

## Full-text entities

- **Diseases:** Gynecologic malignancies (MESH:D005833), tumor (MESH:D009369), ovarian, endometrial, and cervical cancers (MESH:D002575)

## Full text

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## Figures

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## References

51 references — full list in the complete paper: https://tomesphere.com/paper/PMC12868163/full.md

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Source: https://tomesphere.com/paper/PMC12868163