# The protective effect of resveratrol on lupus nephritis mice by up-regulating Sirt1

## TL;DR

Resveratrol protects mice with lupus nephritis by improving kidney function and reducing inflammation and oxidative stress.

## Contribution

This study demonstrates that resveratrol protects lupus nephritis mice by up-regulating Sirt1 expression.

## Key findings

- Resveratrol improved kidney function and reduced proteinuria in MRL/lpr mice.
- Resveratrol inhibited inflammation, oxidative stress, and kidney cell apoptosis.
- Resveratrol increased Sirt1 protein and mRNA expression in mouse kidneys.

## Abstract

To investigate the therapeutic effect and protective mechanism of resveratrol (Res) on mice with lupus nephritis (LN).

We used Res to intervene in MRL/lpr mice and employed biochemical techniques to assess kidney function, inflammation levels, and oxidative stress. We also evaluated changes in immune function and used immunohistochemistry to assess Sirt1 protein and mRNA expression.

Res improved the kidney function, alleviated proteinuria, and renal pathological damage in MRL/lpr mice. Res also ameliorated spleen weight and spleen index, and inhibited urinary protein/creatinine levels. Moreover, Res inhibited the expression of circulating inflammatory factors, oxidative stress levels, and kidney cell apoptosis in MRL/lpr mice. Res effectively promoted Sirt1 protein and mRNA expression in the kidneys of MRL/lpr mice.

Res has a protective effect on MRL/lpr mice, and its mechanism may involve activation of the Sirt1 signaling pathway.