# Towards Personalised Assessment of Abdominal Aortic Aneurysm Structural Integrity

## TL;DR

This paper introduces a new non-invasive method to assess the structural integrity of abdominal aortic aneurysms using 3D imaging and blood pressure data.

## Contribution

The study proposes a novel index, RSII, for personalized AAA assessment that does not rely on wall thickness or material properties.

## Key findings

- RSII values were consistent across patients, showing method reliability.
- AAA walls were stiffer than healthy aortas, with low-stiffness zones in dilated regions.
- The RSII index integrates stress and strain for personalized disease assessment.

## Abstract

Abdominal aortic aneurysm (AAA) is a life‐threatening condition characterized by the progressive dilation of the aorta, which can lead to rupture if undetected or untreated. Stress‐based rupture risk estimation using computational biomechanics has been widely studied; however, it requires wall strength data that cannot be measured in humans in vivo. To overcome this limitation, the goal of this study is to present a new method for biomechanical assessment of AAA via simultaneous consideration of tension and strain in AAA wall. We present a patient‐specific, non‐invasive method for assessing the structural integrity of the AAA wall using only time‐resolved 3D computed tomography angiography (4D‐CTA) images and blood pressure data. The proposed approach integrates wall strain (throughout the cardiac cycle) and wall tension analysis to compute a novel index, the Relative Structural Integrity Index (RSII), which quantifies local wall stiffness independently of wall thickness, wall material properties, and blood pressure measurement conditions. We applied our method to 20 patients from three different hospitals to extract visual RSII maps over the AAA wall of each individual patient and to compare the RSII values between aneurysmal and non‐aneurysmal aortas in one patient. Our results primarily show similar RSII values across all patients, indicating the consistency of the method. Additionally, we observed patterns consistent with experimental findings reported in the literature: AAA walls exhibited higher stiffness than healthy aortic walls, while localized low‐stiffness zones in the AAA wall were predominantly found in the most dilated regions.

We propose the Relative Structural Integrity Index (RSII) as a novel non‐invasive biomarker that integrates wall stress and strain analysis for personalized assessment of abdominal aortic aneurysm (AAA) structural integrity and disease severity, independent of wall thickness, material properties, and blood pressure measurement conditions.