# Hearing Loss: From Basic to Clinical Science

## TL;DR

This collection of 31 papers explores the basic science, gene therapy, and clinical approaches to hearing loss, which affects over 1.5 billion people worldwide.

## Contribution

The collection presents new insights into HL mechanisms, gene therapy applications, and clinical studies.

## Key findings

- Genetic factors account for about 50% of congenital hearing loss cases.
- The collection includes 9 review papers and 21 research articles on HL mechanisms and treatments.
- Gene therapy and clinical applications for HL are highlighted as key areas of focus.

## Abstract

Hearing loss (HL) affects over 1.5 billion people globally, with genetic factors accounting for ≈50% of congenital cases. Therefore, HL has become a global health issue, driving extensive research from basic science to clinical applications. This Special Collection includes a total of 31 papers, among which 9 are review papers, 21 are research article papers, 1 is a perspective paper, that highlight the basic mechanisms and possible protection methods of HL, the application of gene therapy for treating HL, and the clinical study and application in HL.