# Clinical and neuroradiological findings in patients with Anti-AMPAR encephalitis: associations with outcomes

## TL;DR

This paper reviews clinical and brain imaging features of a rare anti-AMPAR encephalitis, finding that MRI results don't strongly predict patient outcomes.

## Contribution

The study expands the known clinical and radiological profile of anti-AMPAR encephalitis through a comprehensive case review.

## Key findings

- Clinical presentations at onset include behavioral, cognitive, motor, and sensory symptoms.
- Neuroradiological findings may extend beyond the limbic system to areas like basal ganglia and cerebellum.
- MRI hyperintensity range does not significantly correlate with clinical symptoms or outcomes.

## Abstract

Encephalitis associated with antibodies against the α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid receptor (AMPAR) is an extremely rare type of antibody-mediated encephalitis. Its clinical phenotype and neuroradiological characteristics remain incompletely described.

We present four cases of anti-AMPAR encephalitis, and a comprehensive literature review highlighted the diverse clinical experiences, with specific attention to the clinical and radiographic characteristics of anti-AMPAR encephalitis, as well as the association between clinical, neuroradiological presentations and outcomes.

A total of 89 patients with anti-AMPAR encephalitis were included in this review. Clinical presentations at the onset of anti-AMPAR encephalitis were diverse, including behavioral, cognitive, motor, and sensory manifestations. Neuroradiological findings cannot be restricted to the limbic system. They may spread to unexpected sites, like basal ganglia, cerebellum, cerebral cortex regions, and even diffuse hyperintensities, or patient may have completely normal brain magnetic resonance imaging (MRI). Fisher’s exact test showed that there was non-significant difference in the clinical symptoms and outcomes among different MRI presentations.Logistic regression analysis showed no significant correlations between clinical, neuroradiological findings and unfavorable outcome.

Anti-AMPAR encephalitis mainly presents as limbic encephalitis, and most of the patients had positive brain MRI results. The range of hyperintensity on MRI may not be directly associated with patients’ clinical symptoms and outcomes. For the expanding clinical profile of encephalitis associated with antibodies against AMPAR, careful databasing of new cases will facilitate more definitive study in the future.