# Regioselective C‑Arylation of Functionalized Nitroalkanes with Furan, Thiophene, and Substituted Thiophenes

**Authors:** Katarína R. Detková, Kristína Jakubcová, Tomáš Malatinský, Juraj Filo, Marek Cigáň, Šimon Budzák, Miroslav Medved’, Pavol Jakubec

PMC · DOI: 10.1021/acs.joc.5c02410 · The Journal of Organic Chemistry · 2025-11-21

## TL;DR

This paper presents a new, efficient method for selectively attaching aromatic groups to nitroalkanes using a one-pot cascade process.

## Contribution

The study introduces a one-pot cascade process for regioselective C-arylation of nitroalkanes with thiophenes and furan.

## Key findings

- The C–H activation occurs under mild conditions.
- The reaction mechanism is supported by experimental and theoretical data.

## Abstract

A user-friendly, highly regioselective C-arylation of
nitroalkanes
with thiophenes and furan, employing a fascinating one-pot cascade
process, has been developed. The formal C–H activation proceeds
under mild conditions and follows a well-understood reaction mechanism
supported by both experimental data and thorough theoretical investigation.

## Linked entities

- **Chemicals:** thiophenes (PubChem CID 8030), furan (PubChem CID 8029)

## Full-text entities

- **Chemicals:** Thiophene (MESH:D013876), Nitroalkanes (-), Furan (MESH:C039281)

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12865766/full.md

## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12865766/full.md

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Source: https://tomesphere.com/paper/PMC12865766